Bouchra Edderkaoui PhD
Research Scientist at the Musculoskeletal Disease Center at VA Loma Linda; Research Assistant Professor at the school of Medicine, Loma Linda University, CA, USA
VA Loma Linda health care
My research program is focused on the study of inflammation and its role on bone loss, hearing loss, fracture healing and osteoarthritis.
Inflammation is observed after infection with foreign body or pathogen, it can also occur after tissue injury, noise exposure or high glucose consumption. Inflammatory reactions have been shown to be powerful activators of monocytes and macrophages and potent inducers of proinflammatory cytokines and chemokines.
We are interested in identifying the chemokines and specific cells involved in each inflammatory model and we have received fundings from US National Institute of health (NIH) and Department of Defense (DOD). We have developed and analyzed different models of inflammation in both mice and rat animals. We have analyzed the infiltration of different inflammatory cells to the injured site, post-bacterial challenge, noise exposure, bone fracture and joint injuries. Our goal is to identify the molecular mediators of bone regeneration, and the mediators of tissue damage post pathogen infection, injury or during osteoarthritis. This can reveal new targets for safe and effective therapies for osteoarthritis and complicated bone healing.
Some of My Publications in the last 6 years.
Edderkaoui B, Sargsyan L, Hetrick A, Li H. Deficiency of Duffy Antigen Receptor for Chemokines Ameliorated Cochlear Damage From Noise Exposure. Front Mol Neurosci. 2018 May 30;11:173. doi: 10.3389/fnmol.2018.00173.
Mohan S, Hu Y, Edderkaoui B. Chemokine receptor 3 is a negative regulator of trabecular bone mass in female mice. J Cell Biochem. 2019 Aug;120(8):13974-13984. doi: 10.1002/jcb.28672.
Subburaman M, Edderkaoui B. Evaluation of CCL21 role in post-knee injury inflammation and early cartilage degeneration. PLoS One. 2021 Mar 2;16(3):e0247913. doi: 10.1371/journal.pone.0247913. Erratum in: PLoS One. 2021 Oct 28;16(10):e0259553.
Quincey A, Mohan S, Edderkaoui B. Monocyte Chemotactic Proteins Mediate the Effects of Hyperglycemia in Chondrocytes: In Vitro Studies. Life (Basel). 2022 Jun 3;12(6):836. doi: 10.3390/life12060836.
Bouchra Edderkaoui. Role of Chemokines in Cartilage Regeneration and Degeneration: New Insights. Submitted to International Journal of Molecular Sciences in December 2023.
List of My Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Edderkaoui%20B