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Multiple Sclerosis Centers of Excellence

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Dimethyl Fumarate (Tecfidera, Generic)

Dimethyl fumarate (Tecfidera) is an oral medication, taken every 12 hours, for the treatment of relapsing forms of MS. Dimethyl fumarate and its metabolites have been shown to activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in vitro and in vivo in animals and humans. The Nrf2 pathway is involved in the cellular response to oxidative stress. Monomethyl fumarate has been identified as a nicotinic acid receptor agonist in vitro. Dimethyl Fumarate Delayed-Release Capsules is an FDA-approved therapeutic equivalent to Tecfidera.

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