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Multiple Sclerosis Centers of Excellence

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Diroximel Fumarate (Vumerity)

Diroximel fumarate (Vumerity) is an oral medication, taken twice daily, for the treatment of relapsing forms of MS. Diroximel fumarate and its active metabolite, monomethyl fumarate (MMF), have been shown to activate the nuclear factor (erythroid-derived 2)-like (Nrf2) pathway, which is involved in cellular response to oxidative stress. MMF has also been identified as a nicotinic acid receptor agonist in vitro.

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