Natalizumab (Tysabri, Tyruko)
Natalizumab and natalizumab-sztn (Tysabri, Tyruko) are medications administered by IV infusion, over one hour every four weeks, for the treatment of relapsing forms of MS. They are theorized to block molecular interaction of alpha-4-beta-integrin expressed by inflammatory cells with VCAM-1 on vascular endothelial cells. The humanized monoclonal antibody binds to alpha 4/beta 1 integrin on activated lymphocytes and monocytes, and blocks leukocyte passage across the blood brain barrier.
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