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Multiple Sclerosis Centers of Excellence

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Ofatumumab (Kesimpta)

Ofatumumab (Kesimpta) is an injectable treatment for relapsing forms of MS to include clinically isolated syndrome, relapsing-remitting disease (RRMS), and active secondary progressive disease, in adults. Ofatumumab is a monoclonal antibody that binds to a docking site (CD20) on developing immune B cells. The binding results in depleting the B cells so that they cannot contribute to inflammation and nerve damage. Ofatumumab is similar to other MS therapies that bind to the CD20 receptor on B cells including rituximab and ocrelizumab. Ofatumumab is administered by subcutaneous injection monthly after an initial titration.

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